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Endocrinology, Vol 109, 301-306, Copyright © 1981 by Endocrine Society

ARTICLES

Adenosine 3',5'-monophosphate (cAMP)-binding proteins and cAMP- dependent protein kinases in bovine adrenal cortical cell plasma membrane

R Reitherman, L Chen, S Wen and BW Harding

A cAMP-binding protein and cAMP-dependent protein kinase have been identified and partially characterized in bovine adrenocortical plasma membranes. [3H]cAMP binding to the plasma membrane preparation demonstrates both high (Ka = 4.2 X 10(9) M-1) and low (Ka = 1.3 X 10(8) M-1) affinity binding sites. cAMP-dependent protein kinase was demonstrated using both bovine histone and endogenous substrates. The detergent-dependent solubilization characteristics of this cAMP- dependent protein kinase indicate that it is an integral membrane protein.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1981 by The Endocrine Society