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Endocrinology, Vol 109, 661-663, Copyright © 1981 by Endocrine Society

ARTICLES

Direct inhibitory effect of GnRH on androgen secretion by ovarian interstitial cells

DA Magoffin, DS Reynolds and GF Erickson

We report here 1) that GnRH and a potent GnRH agonist inhibit basal and LH stimulated ovarian androgen biosynthesis in vitro, 2) that the inhibitory effects of GnRH are dose-dependent and completely inhibited by concomitant treatment with a GnRH antagonist and 3) that the GnRH action is very rapid (t1/2 = 10 min) and persists after thorough washing of the cells. These data suggest that GnRH acts at a stereospecific binding site on ovarian theca and/or interstitial cells (probably the theca cells) to rapidly and perhaps irreversibly inhibit androgen biosynthesis.




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Copyright © 1981 by The Endocrine Society