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Endocrinology, Vol 109, 1301-1302, Copyright © 1981 by Endocrine Society

ARTICLES

Somatomedin generating activity of the 20,000-dalton variant of human growth hormone

EM Spencer, LJ Lewis and UJ Lewis

The 20,000-dalton variant of human growth hormone stimulated production of somatomedins in the hypophysectomized rat. Somatomedin activity was measured by a radioreceptor assay. The results indicate that the insulin--like activities of human growth hormone that are greatly diminished in the variant are not prerequisites for somatomedin production.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
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Copyright © 1981 by The Endocrine Society