help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cheah, S. H.
Right arrow Articles by Sherwood, O. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cheah, S. H.
Right arrow Articles by Sherwood, O. D.

Endocrinology, Vol 109, 2076-2083, Copyright © 1981 by Endocrine Society

ARTICLES

Effects of relaxin on in vivo uterine contractions in conscious and unrestrained estrogen-treated and steroid-untreated ovariectomized rats

SH Cheah and OD Sherwood

The effect of extended infusions of highly purified porcine relaxin on uterine activity was tested in vivo in conscious unrestrained rats. Relaxin was found to inhibit oxytocin- and prostaglandin F2 alpha- induced uterine contractions in estrogen-treated ovariectomized rats as well as spontaneous contractions in both estrogen-treated and steroid- untreated ovariectomized rats. The inhibition of both induced and spontaneous uterine contractions was more effective in the early phases of relaxin infusion than after prolonged exposure to the hormone. However, this desensitization was not complete, and the inhibition was effective even with extended (up to 72 h in the oxytocin experiments) infusion of relaxin. The results indicate that relaxin may be important in controlling uterine activity in the rat near the end of gestation, and that estrogen priming in ovariectomized rats is not necessary for relaxin to exert its biological effects.


This article has been cited by other articles:


Home page
 Ann. N. Y. Acad. Sci.Home page
D J SCOTT, G W TREGEAR, and R A D BATHGATE
LGR7-Truncate Is a Splice Variant of the Relaxin Receptor LGR7 and Is a Relaxin Antagonist in Vitro
Ann. N.Y. Acad. Sci., May 1, 2005; 1041(1): 22 - 26.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
A. L. SIEBEL, H. M. GEHRING, L. VODSTRCIL, and L. J. PARRY
Oxytocin and Estrogen Receptor Expression in the Myometrium of Pregnant Relaxin-Deficient (Rlx-/-) Mice
Ann. N.Y. Acad. Sci., May 1, 2005; 1041(1): 104 - 109.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. L. Siebel, H. M. Gehring, I. G. T. Reytomas, and L. J. Parry
Inhibition of Oxytocin Receptor and Estrogen Receptor-{alpha} Expression, But Not Relaxin Receptors (LGR7), in the Myometrium of Late Pregnant Relaxin Gene Knockout Mice
Endocrinology, October 1, 2003; 144(10): 4272 - 4275.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1981 by The Endocrine Society