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Endocrinology, Vol 110, 288-290, Copyright © 1982 by Endocrine Society

ARTICLES

Ovulation induced by a gonadotropin releasing hormone analog in hypophysectomized rats involves prostaglandins

C Ekholm, MR Clark, C Magnusson, O Isaksson and WJ LeMaire

A potent analogue of gonadotropin releasing hormone [D-Ala6- Des-Gly10- NH2]-GnRH ethylamide (GnRHa) caused oocyte maturation and ovulation when injected in the afternoon of proestrus in immature PMSG-treated female rats, hypophysectomized on the morning of proestrus. This action of GnRHa was accompanied by a marked increase in ovarian PGE levels. Furthermore, the pretreatment of the animals with a prostaglandin synthetase inhibitor (indomethacin) completely inhibited this PGE increase and ovulation. These data suggest a role for prostaglandins in GnRHa induced ovulation.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
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Copyright © 1982 by The Endocrine Society