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Endocrinology, Vol 110, 660-662, Copyright © 1982 by Endocrine Society

ARTICLES

High somatostatin uptake by the isolated perfused dog pancreas consistent with "insulo-acinar" axis

K Kawai, L Orci and RH Unger

The canine pancreas takes up 50-80% of somatostatin perfused over a concentration range of 20 to 4000 pg/ml, compared to less than 21% of insulin or glucagon. This high uptake by acinar tissue of somatostatin, a potent inhibitor of acinar function, is compatible with a system for selective intrapancreatic control of exocrine pancreatic function via the insulo-acinar portal venous system.


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T. C. Brelje, L. E. Stout, N. V. Bhagroo, and R. L. Sorenson
Distinctive Roles for Prolactin and Growth Hormone in the Activation of Signal Transducer and Activator of Transcription 5 in Pancreatic Islets of Langerhans
Endocrinology, September 1, 2004; 145(9): 4162 - 4175.
[Abstract] [Full Text] [PDF]


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