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Endocrinology, Vol 110, 1043-1045, Copyright © 1982 by Endocrine Society

ARTICLES

Binding and activation properties of angiotensin II in dispersed rat anterior pituitary cells

AM Capponi, CA Favrod-Coune, RC Gaillard and AF Muller

The properties of angiotensin II receptors were studied in isolated rat anterior pituitary cells prepared by trypsin digestion. Angiotensin II bound in a time- and temperature-dependent manner to pituitary cells, with Kd of 4.1 x 10(-9) M. The heptapeptide, des-Asp1-angiotensin II, had only one-tenth of the affinity of the octapeptide (Ki = 5.5 x 10(- 8) M). These two peptides displayed a similar potency ratio in their ability to stimulate ACTH release from pituitary cells. These results indicate that angiotensin II may play a regulatory role in controlling ACTH secretion from the pituitary gland.


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