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Endocrinology, Vol 110, 1526-1528, Copyright © 1982 by Endocrine Society

ARTICLES

The course of thyrotropin-releasing hormone fibers to the median eminence in rats

M Palkovits, RL Eskay and MJ Brownstein

The topographical distribution of fibers containing TRH that run to the median eminence has been investigated by RIA of TRH after hypothalamic surgical transections in rats. Anterolateral or lateral cuts bilaterally transecting fibers at the caudal edge of the optic chiasm (lateral retrochiasmatic area) diminish TRH levels in the median eminence by 95% and 73%, respectively. Paramedian cuts are ineffective. These results suggest that TRH fibers reach the medial basal hypothalamus from an anterolateral direction just as several other classes of peptide containing fibers do.




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Copyright © 1982 by The Endocrine Society