help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Quabbe, H. J.
Right arrow Articles by Hardel, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Quabbe, H. J.
Right arrow Articles by Hardel, C.

Endocrinology, Vol 110, 1641-1646, Copyright © 1982 by Endocrine Society

ARTICLES

Pattern of plasma cortisol during the 24-hour sleep/wake cycle in the rhesus monkey

HJ Quabbe, M Gregor, C Bumke-Vogt and C Hardel

The 24-h pattern of plasma cortisol and changes induced by alterations of the sleep/wake cycle were studied in 12 male rhesus monkeys. The chair-living animals were chronically prepared with a right atrial catheter and electroencephalogram electrodes. Hormone (blood samples every 15 min) and continuous activity/electroencephalogram profiles were obtained from the adjacent room for 96 h (4 animals), 24 h or various shorter periods of time. Plasma cortisol showed a circadian rhythm with a late evening minimum (1900-2100 h; approximately 60 micrograms/liter) and an early morning maximum (0400-0700 h; approximately 160 micrograms/liter). Superimposed were episodic fluctuations for which powerspectral analysis showed a weakly expressed 30- to 60-min periodicity in 24 of 27 24-h profiles. Cross-correlation analysis indicated no relation between cortisol on the one hand and daytime activity-arousal, nocturnal waking, slow wave sleep (SWS) or rapid eye movement sleep (REM), respectively. Five-hour total sleep deprivation, specific SWS-deprivation, and severe disruption of the REM- pattern provided no evidence for an immediate effect of sleep onset or sleep stages on the cortisol pattern. Cortisol rose significantly after termination of the 5-h deprivation, but the mechanism of this elevation remains to be determined. Cross-correlation analysis between the cortisol time series and those of GH, PRL, and TSH from already published data gave no evidence for a regular temporal relationship between the episodic patterns of these hormones.


This article has been cited by other articles:


Home page
 EndocrinologyHome page
E. Challet
Minireview: Entrainment of the Suprachiasmatic Clockwork in Diurnal and Nocturnal Mammals
Endocrinology, December 1, 2007; 148(12): 5648 - 5655.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Vicentic, G. Dominguez, R. G. Hunter, K. Philpot, M. Wilson, and M. J. Kuhar
Cocaine- and Amphetamine-Regulated Transcript Peptide Levels in Blood Exhibit a Diurnal Rhythm: Regulation by Glucocorticoids
Endocrinology, September 1, 2004; 145(9): 4119 - 4124.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. H. Broadbear, G. Winger, T. J. Cicero, and J. H. Woods
Effects of Self-Administered Cocaine on Plasma Adrenocorticotropic Hormone and Cortisol in Male Rhesus Monkeys
J. Pharmacol. Exp. Ther., June 1, 1999; 289(3): 1641 - 1647.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1982 by The Endocrine Society