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Endocrinology, Vol 110, 1822-1824, Copyright © 1982 by Endocrine Society

ARTICLES

Evidence for two species of insulin-like growth factor II (IGF II and "big" IGF II) in human spinal fluid

G Haselbacher and R Humbel

Human serum contains the somatomedins, insulin-like growth factor I and II (IGF I and II). In spinal fluid, however, only IGF II was found in measurable and significant amounts. In addition, an IGF II of larger mass could be detected by a radioimmunoassay for IGF II. This "big" IGF II is biologically active and has an apparent molecular weight of 9000.


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