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Restitution of Blood Volume after Hemorrhage: Inhibition by Somatostatin^*

Sections of Physiology/Biophysics and Surgery, Brown University, Rhode Island Hospital, Providence, Rhode Island 02902

Address requests for reprints to: Dr. D. S. Gann, Department of Surgery, Brown University, Rhode Island Hospital 02902.

Abstract

To determine whether glucagon plays a significant role in the restitution of blood volume after hemorrhage, pentobarbital-anesthetized dogs were treated with somatostatin (SRIF). The administration of SRIF (14 µ/h) prevented the increase in osmolality and the complete restitution of plasma protein and blood volume that normally occur after 10% hemorrhage. The intraportal addition of glucagon (20 ng/kg-min) during the initial 4 h after hemorrhage reversed the SRIFinduced block in hyperosmolality and was followed by complete restitution of plasma protein and blood volume. These data suggest that increases in glucagon may be a part of the multihormonal response to hemorrhage, and this may be a part of a reflex that mediates the homeostasis of blood volume.

Footnotes

^* This work was supported in part by NIH Research Grant GM-27946.

Received September 18, 1981.

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