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Urinary 19-Nor-Deoxycorticosterone Excretion in the Spontaneously Hypertensive Rat^*

Evans Memorial Department of Clinical Research and Departments of Medicine and Physiology, University Hospital, Boston University Medical Center, Boston, Massachusetts 02118

Address requests for reprints to: James C. Melby, M.D., University Hospital, 75 East Newton Street, Boston, Massachusetts 02118.

Abstract

Urinary free 21-hydroxy-19-nor-4-pregnen-3,20-dione (19-nor-DOC) excretion in male and female spontaneously hypertensive rats (SHR) and the normotensive Wistar Kyoto (WKY) strain of rat was measured at weekly intervals from weaning (at 3 weeks of age) to 7 weeks of age. Excretion of this steroid was found to be elevated in both male and female SHR compared to WKY rats before the development of hypertension at 8 weeks of age. Urinary levels of 19-nor-DOC returned to WKY at levels 1 week earlier in the male SHR than in the female SHR The levels of 19-nor-DOC in female SHR returned to the level in the female WKY rat just before the onset of hypertension.

Footnotes

^* This work was supported by Grants-in-Aid 5-PO-HL-18318, 5-RO1-AM-12027, 5-P32-HL-07224, and 1-T30-AM-21683 SCOR from the NIH.

Received August 31, 1981.