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Prolactin Status of Hereditary Dwarf Mice^*

Department of Animal Physiology, University of California, Davis, California 95616
the Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284
the Department of Human Anatomy, School of Medicine, University of California, Davis, California 95616
the Lutcher Brown Center for Diabetes and Endocrinology, Scripps Clinic and Research Foundation, La Jolla, California 92037

Address requests for reprints to: M. S. Barkley, Department of Animal Physiology, University of California, Davis, Davis, California 95616.

Abstract

Snell (dw/dw) and Ames (df/df) dwarf mice of both sexes were evaluated for immunoassayable PRL in plasma and for the presence of PRL-containing cells in the hypophysis. Regardless of the method of blood collection (decapitation or cardiac or orbital puncture), minimal concentrations of PRL were detected in the plasma of hereditary dwarf mice. PRL secretion was not augmented in Snell or Ames female dwarfs after treatment with perphenazine or estradiol benzoate, stimuli which greatly increased PRL release in normal female littermates. Comparison of PRL levels in dwarf animals (dw/dw or df/df) using two different homologous RIAs substantiated the observation that male and female dwarfs are PRL deficient. Mammotropes, readily detectable in the pituitary glands of all normal siblings of Snell and Ames mice, were absent from the dwarf mouse hypophysis, which was markedly reduced in size. The lack of PRL-containing cells in the dwarf mouse p tuitary may explain why peripheral PRL levels in this animal are below those measured in hypophysectomized mice.

Footnotes

^* This work was supported by Grants HD-00394, HD-12642, and CA-18664 from the NIH.

Received June 26, 1981.

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