Endocrinology, Vol 110, 2097-2100, Copyright © 1982 by Endocrine Society

ARTICLES

Adrenocorticotropin, and corticosterone secretion in Brattleboro rats

B Conte-Devolx, C Oliver, P Giraud, E Castanas, F Boudouresque, P Gillioz and Y Millet

Brattleboro rats which lack endogenous vasopressin have been used to study the role of vasopressin as a corticotropin-releasing factor. Plasma ACTH, beta-endorphin, and corticosterone were measured by RIA in male and female Long-Evans and Brattleboro rats under the following conditions: unstressed, after ether stress, after nicotine injection, and after adrenalectomy. A significant reduction in the ACTH, beta- endorphin, and corticosterone responses to the different experimental procedures was observed in the Brattleboro rats. However, in this strain of rats, a significant increase in the release of all three hormones was obtained, suggesting that vasopressin has only a synergistic role in the regulation of their secretion.

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