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Endocrinology, Vol 110, 2210-2212, Copyright © 1982 by Endocrine Society

ARTICLES

Noncarbohydrate nutrients protect against alloxan-induced inhibition of insulin release

A Sener, F Malaisse-Lagae and WJ Malaisse

Noncarbohydrate nutrients such as 2-ketoisocaproate, L-glutamine, L- leucine and its nonmetabolized analog, beta-2- aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH) were able to mimic, to a limited extent, the protective action of D-glucose against the inhibitory effect of alloxan on glucose-stimulated insulin release. L- glutamine potentiated the protective action of BCH but not that of 2- ketoisocaproate or L-leucine. These data lend support to the view that the cytotoxic effect of alloxan is linked to the generation of peroxide. Agents which stimulate islet metabolism may protect against such a cytotoxic effect by increasing the production rate of reducing equivalents in the islet cells.




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Copyright © 1982 by The Endocrine Society