| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Endocrinology, Vol 110, 2219-2221, Copyright © 1982 by Endocrine Society
ARTICLES |
LZ Zhuang, EY Adashi and AJ Hsuch
The biosynthesis of ovarian aromatases and hence estrogen production are under the control of the gonadotropins, FSH and LH. Using a primary culture of rat granulosa cells, we now report that estrogens (diethylstilbestrol and 17 beta-estradiol) augment the stimulation of aromatase activity by FSH and LH. Moreover, clomiphene citrate, a drug widely used to induce ovulation in anovulatory women, also enhances gonadotropin-stimulated aromatase activity. These in vitro findings suggest that estrogens within the microenvironment of the ovarian follicles may exert a local autoregulatory effect on their own production via an ultra-short loop, positive feedback mechanism. In addition, the clinical efficacy of clomiphene citrate may derive partially from its direct augmentation of the gonadotropin-stimulated estrogen production at the ovarian level.
This article has been cited by other articles:
 |
|
 |
|
  K. D. CARPENTER and K. S. KORACH Potential Biological Functions Emerging from the Different Estrogen Receptors Ann. N.Y. Acad. Sci., December 1, 2006; 1092(1): 361 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Otsuka, R. K. Moore, X. Wang, S. Sharma, T. Miyoshi, and S. Shimasaki Essential Role of the Oocyte in Estrogen Amplification of Follicle-Stimulating Hormone Signaling in Granulosa Cells Endocrinology, August 1, 2005; 146(8): 3362 - 3367. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Couse, M. M. Yates, B. J. Deroo, and K. S. Korach Estrogen Receptor-{beta} Is Critical to Granulosa Cell Differentiation and the Ovulatory Response to Gonadotropins Endocrinology, August 1, 2005; 146(8): 3247 - 3262. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. A. Emmen, J. F. Couse, S. A. Elmore, M. M. Yates, G. E. Kissling, and K. S. Korach In Vitro Growth and Ovulation of Follicles from Ovaries of Estrogen Receptor (ER){alpha} and ER{beta} Null Mice Indicate a Role for ER{beta} in Follicular Maturation Endocrinology, June 1, 2005; 146(6): 2817 - 2826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. A. Perry, M. F. Smith, M. C. Lucy, J. A. Green, T. E. Parks, M. D. MacNeil, A. J. Roberts, and T. W. Geary From the Cover: Relationship between follicle size at insemination and pregnancy success PNAS, April 5, 2005; 102(14): 5268 - 5273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Sundarrajan, W.-X. Liao, A.C. Roy, and S.C. Ng Association of oestrogen receptor gene polymorphisms with outcome of ovarian stimulation in patients undergoing IVF Mol. Hum. Reprod., September 1, 1999; 5(9): 797 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Couse and K. S. Korach Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us? Endocr. Rev., June 1, 1999; 20(3): 358 - 417. [Abstract] [Full Text]
|
|
|
|
|
|
J. H. Krege, J. B. Hodgin, J. F. Couse, E. Enmark, M. Warner, J. F. Mahler, M. Sar, K. S. Korach, J.-A. Gustafsson, and O. Smithies Generation and reproductive phenotypes of mice lacking estrogen receptor beta PNAS, December 22, 1998; 95(26): 15677 - 15682. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
