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Endocrinology, Vol 111, 1403-1405, Copyright © 1982 by Endocrine Society

ARTICLES

Epinephrine synthesis inhibitors block naloxone-induced LH release

SP Kalra and WR Crowley

Administration of the opiate receptor antagonist, naloxone, evoked rapid rises in plasma LH levels in estrogen, progesterone-primed ovariectomized rats. Pretreatment with a peripherally acting epinephrine (EPI) synthesis inhibitor, SK&F 29661, failed to influence the naloxone-induced LH release. However, two centrally acting EPI synthesis inhibitors, SK&F 64139 and LY 78335, which selectively suppressed hypothalamic EPI levels, blocked stimulation of LH release by naloxone. These results implicate brain EPI neurons in mediation of endogenous opioid peptide influence on LH release.


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M. I. Sannella and S. L. Petersen
Dual Label in Situ Hybridization Studies Provide Evidence that Luteinizing Hormone-Releasing Hormone Neurons Do Not Synthesize Messenger Ribonucleic Acid for {micro}, {kappa}, or {delta} Opiate Receptors
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[Abstract] [Full Text] [PDF]


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