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Endocrinology, Vol 112, 405-407, Copyright © 1983 by Endocrine Society

ARTICLES

Progestin augmentation of gonadotropin-stimulated progesterone production by cultured rat granulosa cells

LF Fanjul, CM Ruiz de Galarreta and AJ Hsueh

Ovarian progesterone production is stimulated by FSH and LH. Concomitant treatment with a synthetic progestin, R5020, (10(-6)M) increases the FSH-stimulated production of progesterone and 20 alpha- hydroxypregn-4-en-3-one (20 alpha-OH-P) in cultured rat granulosa cells. Likewise, R5020 augments the LH-stimulated progestin production in FSH-primed cells. Furthermore, the FSH stimulation of pregnenolone biosynthesis is enhanced by 10(-6) M of progesterone or R5020. These in vitro findings suggest that progestins may exert an autoregulatory positive feedback action to enhance gonadotropin-stimulated production of progesterone and 20 alpha-OH-P.


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