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Endocrinology, Vol 112, 761-762, Copyright © 1983 by Endocrine Society

ARTICLES

Platelet-derived growth factor stimulates bone resorption by monocyte monolayers

LL Key Jr, DL Carnes Jr, R Weichselbaum and CS Anast

Resorption of devitalized bone particles by monocytes grown in culture was stimulated by platelet-derived growth factor (PDGF) in a dose- dependent manner. Bone resorption in response to PDGF was time- dependent with a significant increase over control cultures evident by 72 hours. These data are the first to demonstrate stimulation of bone resorption by PDGF in a specific cell type known to resorb bone in vivo and in vitro.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1983 by The Endocrine Society