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Endocrinology, Vol 112, 1133-1134, Copyright © 1983 by Endocrine Society

ARTICLES

Expression of the prolactin gene in human decidua-chorion

J Clements, P Whitfeld, N Cooke, D Healy, B Matheson, J Shine and J Funder

Messenger RNA (mRNA) purified from human decidua-chorion hybridizes with a 32P-cDNA probe for human prolactin. In contrast, mRNA from human trophoblast and amnion does not hybridize to prolactin cDNA. The migration position on agarose gels of prolactin-specific mRNA from human decidua-chorion is similar to that for mRNA from ovine pituitary, suggesting a similar sized mRNA coding for prolactin in these different tissues and species. These data demonstrate unambiguously that the prolactin gene is expressed in human decidua-chorion, confirming previous immunochemical reports of prolactin production by this tissue in culture.


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