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Endocrinology, Vol 112, 951-955, Copyright © 1983 by Endocrine Society

ARTICLES

Location of thyrotropin-releasing hormone-like immunoreactivity in rat pancreas

H Kawano, S Daikoku and S Saito

The location of TRH-like immunoreactivity (TRH-LI) was determined in developing rat pancreas (20.5 and 22.5 days of gestation, 1, 3, and 8 days, and 3 months after birth). The pancreatic tissue was freeze-dried and fixed in acrolein or paraformaldehyde vapor, and paraffin sections (2 microns) were prepared for immunostaining. TRH-LI was detected only in the islets. On day 20.5 of gestation, a few cells contained TRH-LI. During development, cells bearing TRH-LI increased in number and were most numerous in the early neonatal period (1-3 days). Then their number decreased again from 8 days after birth; in adult rats the immunoreactivity was too weak to allow identification of TRH-LI- positive cells. The topographical relation of TRH-LI with other islet hormones was studied in serial sections from perinatal rats stained with different antisera. TRH-LI was found in almost all cells containing insulin and in some containing glucagon, but not in those containing somatostatin.


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M. Yamada, Y. Saga, N. Shibusawa, J. Hirato, M. Murakami, T. Iwasaki, K. Hashimoto, T. Satoh, K. Wakabayashi, M. M. Taketo, et al.
Tertiary hypothyroidism and hyperglycemia in mice with targeted disruption of the thyrotropin-releasing hormone gene
PNAS, September 30, 1997; 94(20): 10862 - 10867.
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