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Is the Postovulatory Release of Follicle-Stimulating Hormone in the Rabbit Mediated by Luteinizing Hormone-Releasing Hormone?^*

Department of Endocrinology (T.M.M., J.A.C.), Medical College of Georgia Augusta, Georgia 30912
Veterans Administration Medical Center and Tulane University School of Medicine New Orleans, Louisiana 70146

Address all correspondence and requests for reprints to: Thomas M. Mills, Ph.D., Department of Endocrinology, Medical College of Georgia, Augusta, Georgia 30912.

Abstract

Studies were performed to determine whether the postovulatory secretion of FSH in the rabbit is an LHRHmediated event. Does were mated and then injected at 12 and 18 h postcoitum with pentobarbital (30 mg/kg BW), an agent known to block endogenous LHRH release. The injection of this barbiturate had no measurable effect on the postovulatory FSH secretion pattern. Administration of the LHRH antagonist [Ac- D-p-Cl-Phe^1,2, Phe³, D-Arg⁶, D-Ala¹⁰]LHRH (0.5 mg/doe) prevented all gonadotropin release in response to LHRH injection (10 µg/kg BW). When this same dose of the antagonist was injected at 18 h postcoitum, the postovulatory FSH secretion pattern was unaffected. Finally, to prove that the pituitary was sensitive to LHRH at 18-h postcoitum, LHRH (10 µg/kg BW) was injected into rabbits mated 18 h earlier; this treatment led to a marked increase in FSH secretion showing that the pituitary is responsive to LHRH at this time. The results of this study show that two drugs which block LHRH-mediated gonadotropin release have no effect on the postovulatory secretion of FSH and support the concept that this episode of FSH secretion occurs via a pathway which does not include the hypothalamic secretion of LHRH.. (Endocrinology 113: 1020, 1983)

Footnotes

^* Supported in part by Grants HD-16431, BRSG-S-07RR05365-21, and NICHD Contract HD-0-2831.

Received October 14, 1982.