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Endocrinology, Vol 113, 903-906, Copyright © 1983 by Endocrine Society

ARTICLES

Effects of metoclopramide on plasma corticosteroid levels in sheep

JR Sowers, FW Beck, N Stern and N Asp

This study investigated the role of dopaminergic mechanisms in modulation of corticosteroid secretion in sheep. Administration of the dopamine antagonist metoclopramide (200 micrograms/kg iv) in six mature sheep resulted in rapid and parallel rises in plasma cortisol, corticosterone, 18-hydroxycorticosterone, and aldosterone. Treatment of the sheep with 4 mg dexamethasone im every 6 h for 4 days abolished the response of all four corticosteroids to metoclopramide in the six sheep. These observations suggest that metoclopramide may stimulate corticosteroid secretion in sheep via nonspecific stressor effects.


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A. Ahmadzadeh, M. A. Barnes, F. C. Gwazdauskas, and R. M. Akers
Dopamine antagonist alters serum cortisol and prolactin secretion in lactating Holstein cows.
J Dairy Sci, June 1, 2006; 89(6): 2051 - 2055.
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