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Effects of Metoclopramide on Plasma Corticosteroid Levels in Sheep^*

JAMES R. SOWERS, FRANCES W. J. BECK, NAFTALI STERN and NORMAN ASP

Richmond Veterans Administration Medical Center Richmond, Virginia 23249;
Sepulveda Veterans Administration Medical Center Sepulveda, California 91343

Address communications and requests for reprints to: James R.Sowers, M.D., Department of Medicine, Veterans Administration Medical Center, Richmond, Virginia 23249.

Abstract

This study investigated the role of dopaminergic mechanisms in modulation of corticosteroid secretion in sheep. Administration of the dopamine antagonist metoclopramide (200 µg/kg iv) in six mature sheep resulted in rapid and parallel rises in plasma cortisol, corticosterone, 18-hydroxycorticosterone, and aldosterone. Treatment of the sheep with 4 mg dexamethasone im every 6 h for 4 days abolished the response of all four corticosteroids to metoclopramide in the six sheep. These observations suggest that metoclopramide may stimulate corticosteroid secretion in sheep via nonspecific stressor effects. (Endocrinology 113: 903, 1983)

Footnotes

^* This work was supported by a Veterans Administration grant.

Present affiliation: Department of Medicine, VA Medical Center,Richmond, VA 23249.

Received October 4, 1982.

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