Endocrinology, Vol 113, 1907-1909, Copyright © 1983 by Endocrine Society

ARTICLES

Estrogen-induced creatine kinase in the reproductive system of the immature female rat

SD Malnick, A Shaer, H Soreq and AM Kaye

An increase in the biosynthetic rate of the brain-type isozyme of creatine kinase (CKBB, first described in the uterus as the "estrogen- induced protein") was found in the ovary, vagina and estrogen receptor- rich regions of the brain (preoptic area, anterior hypothalamus and median eminence), one hour after injection of 5 micrograms of estradiol- 17 beta into 25-28 day-old rats. The increase in synthetic rate in the ovary, detected by 35S methionine incorporation, peaked at 1h, but still remained higher than in control ovaries at 6 h and was reflected in a longer-term increase in ovarian CK specific activity after 4 daily injections. Both ovary and vagina, similarly to brain, contained exclusively the BB isozyme of CK. These findings suggest that the entire female reproductive system can respond to estrogen by a rapid induction of CKBB.

This article has been cited by other articles:

				S. Tamir, M. Eizenberg, D. Somjen, N. Stern, R. Shelach, A. Kaye, and J. Vaya Estrogenic and Antiproliferative Properties of Glabridin from Licorice in Human Breast Cancer Cells Cancer Res., October 1, 2000; 60(20): 5704 - 5709. [Abstract] [Full Text]

				D. Somjen, F. Kohen, A. Jaffe, Y. Amir-Zaltsman, E. Knoll, and N. Stern Effects of Gonadal Steroids and Their Antagonists on DNA Synthesis in Human Vascular Cells Hypertension, July 1, 1998; 32(1): 39 - 45. [Abstract] [Full Text] [PDF]