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Endocrinology, Vol 114, 761-766, Copyright © 1984 by Endocrine Society

ARTICLES

Forskolin stimulates adenylate cyclase activity, adenosine 3',5'- monophosphate production and peptide release from the intermediate lobe of the rat pituitary gland

K Miyazaki, ME Goldman and JW Kebabian

Forskolin stimulates adenylate cyclase activity in a cell-free homogenate of the intermediate lobe (IL) of the rat pituitary gland. L- Isoproterenol, a beta-adrenergic agonist, enhances and apomorphine, a D- 2 agonist, inhibits the forskolin-stimulated adenylate cyclase activity. Guanosine triphosphate is obligatory for the dopaminergic attenuation of the forskolin-enhanced enzyme activity. When tested upon enzymatically dispersed IL cells, forskolin enhances the release of both cAMP and immunoreactive alpha MSH-like peptides. These effects of forskolin upon the IL are discussed within the context of a previously published working hypothesis that cAMP in some way triggers the calcium- dependent release of hormones from the IL.




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Copyright © 1984 by The Endocrine Society