Endocrinology, Vol 114, 801-805, Copyright © 1984 by Endocrine Society

ARTICLES

Vitamin A and follicle-stimulating hormone synergistically induce differentiation of type A spermatogonia in adult mouse cryptorchid testes in vitro

T Haneji, M Maekawa and Y Nishimune

To study the mechanism of vitamin A and FSH action on testicular germ cell differentiation, artificially induced cryptorchid testes of adult mice were cultured in vitro, because such testes contain only type A spermatogonia and Sertoli cells in their seminiferous tubules. A synergistic effect of vitamin A compounds with FSH, but not with LH, on testicular germ cell differentiation was observed. Our data suggested that FSH stimulated the proliferation of type A spermatogonia, whereas retinoids induce spermatogenesis from type A spermatogonia into intermediate or type B spermatogonia. Possible mechanisms of action of retinoids and FSH on testicular germ cell differentiation are discussed.

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