Endocrinology, Vol 114, 1546-1549, Copyright © 1984 by Endocrine Society

ARTICLES

Central nervous system regulation of adrenocorticotropin secretion: role of somatostatins

MR Brown, C Rivier and W Vale

Somatostatin-28 (SS-28) and desAA1,2,4,5,12,13[D-Trp8]somatostatin (ODT8-SS), but not somatostatin-14, given intracerebroventricularly, but not when given iv, inhibit stress-induced pituitary ACTH and adrenomedullary epinephrine secretion in rats. The elevation of ACTH after tail-suspension stress is totally prevented by iv administration of antisera raised against corticotropin-releasing factor (CRF). SS-28 and ODT8-SS do not inhibit CRF-induced ACTH secretion in vivo or in vitro. These results are consistent with the hypothesis that SS-28 and ODT8-SS prevent stress-induced ACTH secretion by inhibition of CRF release.

This article has been cited by other articles:

				R. Pastor, C. S. McKinnon, A. C. Scibelli, S. Burkhart-Kasch, C. Reed, A. E. Ryabinin, S. C. Coste, M. P. Stenzel-Poore, and T. J. Phillips From the Cover: Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: A urocortin1-independent mechanism PNAS, July 1, 2008; 105(26): 9070 - 9075. [Abstract] [Full Text] [PDF]

				R Giordano, A Picu, L Bonelli, F Broglio, F Prodam, S Grottoli, G Muccioli, E Ghigo, and E Arvat The activation of somatostatinergic receptors by either somatostatin-14 or cortistatin-17 often inhibits ACTH hypersecretion in patients with Cushing's disease Eur. J. Endocrinol., October 1, 2007; 157(4): 393 - 398. [Abstract] [Full Text] [PDF]

				A. Iranmanesh, P. C. Carpenter, K. Mielke, C. Y. Bowers, and J. D. Veldhuis Putative Somatostatin Suppression Potentiates Adrenocorticotropin Secretion Driven by Ghrelin and Human Corticotropin-Releasing Hormone J. Clin. Endocrinol. Metab., September 1, 2007; 92(9): 3653 - 3659. [Abstract] [Full Text] [PDF]

				E Zoumakis, D K Grammatopoulos, and G P Chrousos Corticotropin-releasing hormone receptor antagonists Eur. J. Endocrinol., November 1, 2006; 155(suppl_1): S85 - S91. [Abstract] [Full Text] [PDF]

				J. van der Hoek, M. Waaijers, P. M. van Koetsveld, D. Sprij-Mooij, R. A. Feelders, H. A. Schmid, P. Schoeffter, D. Hoyer, D. Cervia, J. E. Taylor, et al. Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells Am J Physiol Endocrinol Metab, August 1, 2005; 289(2): E278 - E287. [Abstract] [Full Text] [PDF]

				L. J Hofland, J. van der Hoek, R. Feelders, M. O van Aken, P. M van Koetsveld, M. Waaijers, D. Sprij-Mooij, C. Bruns, G. Weckbecker, W. W de Herder, et al. The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5 Eur. J. Endocrinol., April 1, 2005; 152(4): 645 - 654. [Abstract] [Full Text] [PDF]

				V. Martínez, J. Rivier, D. Coy, and Y. Taché Intracisternal Injection of Somatostatin Receptor 5-Preferring Agonists Induces a Vagal Cholinergic Stimulation of Gastric Emptying in Rats J. Pharmacol. Exp. Ther., June 1, 2000; 293(3): 1099 - 1105. [Abstract] [Full Text]

				S. Craft, S. Asthana, J. W. Newcomer, C. W. Wilkinson, I. T. Matos, L. D. Baker, M. Cherrier, C. Lofgreen, S. Latendresse, A. Petrova, et al. Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose Arch Gen Psychiatry, December 1, 1999; 56(12): 1135 - 1140. [Abstract] [Full Text] [PDF]

				D. Engler, E. Redei, and I. Kola The Corticotropin-Release Inhibitory Factor Hypothesis: A Review of the Evidence for the Existence of Inhibitory as Well as Stimulatory Hypophysiotropic Regulation of Adrenocorticotropin Secretion and Biosynthesis Endocr. Rev., August 1, 1999; 20(4): 460 - 500. [Abstract] [Full Text] [PDF]