This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by KLEIN, L. E. Articles by LO, C. S. Search for Related Content PubMed PubMed Citation Articles by KLEIN, L. E. Articles by LO, C. S.

Regulation of Rat Renal (Na⁺+K⁺)-Adenosine Triphosphatase Activity by Triiodothyronine and Corticosterone^*

Department of Physiology, Uniformed Services University of the Health Sciences Bethesda, Maryland 20814

Address all correspondence and requests for reprints to: C. S. Lo, Ph.D., Department of Physiology, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, Maryland 20814.

Abstract

The present study concerns the effects of corticosterone and T₃ on renal cortical and outer medullary NaKATPase activities in the rat. The results show that corticosterone increases cortical and outer medullary NaK-ATPase activities when administered as either a single or multiple doses. Corticosterone and T₃ are known to enhance NaK-ATPase activity. We investigate the possibility of interaction between the effects of corticosterone and T₃ on renal NaK-ATPase activity. Our studies indicate that corticosterone and T₃ regulate renal cortical NaK-ATPase activity via parallel independent pathways, and that corticosterone appears to regulate medullary NaK-ATPase activity without participation by thyroid hormone. (Endocrinology 115: 1038–1042, 1984)

Footnotes

^* This work was supported by USUHS Grant C07623 and NIH Grant AM-28590.

Received December 28, 1983.

This article has been cited by other articles:

				B. Vogt, B. Dick, H.-P. Marti, F. J. Frey, and B. M. Frey Reduced 11{beta}-hydroxysteroid dehydrogenase activity in experimental nephrotic syndrome Nephrol. Dial. Transplant., May 1, 2002; 17(5): 753 - 758. [Abstract] [Full Text] [PDF]