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Association of Spontaneous Thyroiditis with the Major Histocompatibility Complex of the Rat^*

McGill University-Montreal Childrens Hospital Research Institute and the Transplantation Service, Royal Victoria Hospital Montreal, Quebec, Canada

Address requests for reprints to: Eleanor Colle, MD, Division of Endocrinology, Montreal Childrens Hospital, 2300 Tupper Street, Montreal, Quebec H3H 1P3 Canada.

Abstract

Overt insulin-dependent diabetes mellitus in the rat is associated with the u haplotype of the rat major histocompatibility complex (MHC), RTl. Thyroiditis of sufficient severity to result in elevation of TSH levels is seen in Buffalo rats (RTl^b). In order to examine the association of autoimmune thyroid disease with MHC gene products, we have crossed inbred Buffalo rats with diabetic BB rats and examined the RTl genotype, the histology of thyroid and pancreatic tissue, and two indices of thyroid function. The data indicate that animals having pancreatic lymphocytic infiltration and insulinopenic overt diabetes mellitus had at least one RTlu haplotype. All but one animal having severe histological thyroid lymphocytic infiltration had at least one RTl^b haplotype. Rats with severe thyroiditis had higher mean TSH levels than rats with normal histology or rats with mild thyroiditis. We conclude that gene products of the rat MHC affect the severity of spontaneous organ-specific autoimmune disease in terms of clinically apparent as well as tissue inflammatory disease. (Endocrinology 116: 1243-1247,1985)

Footnotes

^* This work was supported by grants from the Medical Research Council of Canada, the Juvenile Diabetes Foundation, and the Canadian Diabetes Association.

Received August 3, 1984.

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