This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Copyright Permission Citing Articles Citing Articles via Google Scholar Google Scholar Articles by FREGLY, M. J. Articles by LUTTGE, W. G. Search for Related Content PubMed PubMed Citation Articles by FREGLY, M. J. Articles by LUTTGE, W. G.

Effect of Chronic Administration of Deoxycorticosterone Acetate on Salt Appetite of Captopril-Treated Rats^*

Departments of Physiology, Psychology, and Neuroscience, Colleges of Medicine and Liberal Arts and Sciences, University of Florida Gainesville, Florida 32610

Address requests for reprints to: Dr. Melvin J. Fregly, Department of Physiology, University of Florida, College of Medicine, Gainesville, Florida 32610.

Abstract

Chronic dietary administration of the angiotensin I-converting enzyme inhibitor, captopril (1.0 g/kg food), induced an appetite for 0.15 M NaCl solution relative to distilled water in a two-bottle ad libitum access paradigm. Graded doses of deoxycorticosterone acetate (DOCA) were administered to the captopril-treated rats via Silastic tubes implanted sc. A Ushaped dose-response relationship was observed between dose of DOCA and intake of 0.15 M NaCl solution. The lowest intake of NaCl occurred with a dose of 102.1 ng DOCA/day (333 µg/kg·day). Water and food intakes were not affected significantly. At the end of the first week of treatment with DOCA, pilocarpine (3.0 mg/kg, ip.)-stimulated salivary chloride concentration was measured. The relationship between salivary chloride concentration and mean intake of 0.15 M NaCl solution was also U shaped, with the minimal NaCl intake associated with a salivary chloride concentration of 54 meq/liter. During the second week of treatment with DOCA, all rats were offered a choice between 0.25 M NaCl solution and distilled water. Rats receiving DOCA at doses of 102.1 µg/day or greater had a significantly lower intake of NaCl solution than those receiving either captopril alone or 66.5 µg DOCA/day in combination with captopril. These results indicate that the appetite for NaCl solution induced by captopril can be inhibited by concurrent administration of DOCA. They also suggest that changes in the concentration of electrolytes in saliva may be associated with changes in the appetite for NaCl solution. (Endocrinology 116:1391-1398, 1985)

Footnotes

^* This work was supported by NIH Grant AM-31837-02.

¹ 21-Acetyloxypregn-4-ene-3,20-dione 21-acetate.

Received May 23, 1984.