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Endocrinology, Vol 116, 2122-2124, Copyright © 1985 by Endocrine Society

ARTICLES

TSH crosslinks to the TSH receptor through the beta subunit

PR Buckland, TW Strickland, JG Pierce and BR Smith

TSH binds specifically to the TSH receptor present on the surface of thyroid follicular cells and consequently activates adenylate cyclase. It was not known, however, which of the two subunits of the TSH bound to the receptor. By covalently crosslinking TSH to its receptor and characterizing the product with antisera specific for either the alpha or beta subunit of TSH, we have shown that the TSH beta subunit but not the TSH alpha subunit crosslinks to the TSH receptor.




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Copyright © 1985 by The Endocrine Society