| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Endocrinology, Vol 116, 2167-2173, Copyright © 1985 by Endocrine Society
ARTICLES |
J Vanecek, D Sugden, J Weller and DC Klein
The adrenergic control of cAMP and 3',5'-cyclic GMP (cGMP) in dispersed adult rat pinealocytes was investigated. Norepinephrine treatment increased cAMP and cGMP content 60- and 400-fold, respectively; both alpha- and beta-adrenoceptors had to be activated for these responses to occur. Beta-Adrenergic stimulation alone produced only about 6- and 2-fold increase in cAMP and cGMP content, respectively. Alpha- Adrenergic stimulation, which alone had no effect on either cyclic nucleotide concentration, markedly amplified the beta-adrenergic stimulation of both cAMP and cGMP. The relative potency of alpha- adrenergic agonists and antagonists indicates the alpha 1-subclass of adrenoceptors is involved. A role of alpha 1-adrenoceptors in the control of pineal cAMP is consistent with published evidence of the presence of alpha 1-adrenoceptors on pinealocytes and their role in the regulation of N-acetyltransferase activity and melatonin production.
This article has been cited by other articles:
 |
|
 |
|
  J.-S. Kim, M. J. Bailey, A. K. Ho, M. Moller, P. Gaildrat, and D. C. Klein Daily Rhythm in Pineal Phosphodiesterase (PDE) Activity Reflects Adrenergic/3',5'-Cyclic Adenosine 5'-Monophosphate Induction of the PDE4B2 Variant Endocrinology, April 1, 2007; 148(4): 1475 - 1485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-Y. Lee, B.-H. Choi, E.-M. Hur, J.-H. Lee, S.-J. Lee, C. O. Lee, and K.-T. Kim Norepinephrine activates store-operated Ca2+ entry coupled to large-conductance Ca2+-activated K+ channels in rat pinealocytes Am J Physiol Cell Physiol, April 1, 2006; 290(4): C1060 - C1066. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. SCHOMERUS and H.-W. KORF Mechanisms Regulating Melatonin Synthesis in the Mammalian Pineal Organ Ann. N.Y. Acad. Sci., December 1, 2005; 1057(1): 372 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Chik, M. Mackova, D. Price, and A. K. Ho Adrenergic Regulation and Diurnal Rhythm of p38 Mitogen-Activated Protein Kinase Phosphorylation in the Rat Pineal Gland Endocrinology, November 1, 2004; 145(11): 5194 - 5201. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. A. Link, F. Ledo, B. Torres, M. Palczewska, T. M. Madsen, M. Savignac, J. P. Albar, B. Mellstrom, and J. R. Naranjo Day-Night Changes in Downstream Regulatory Element Antagonist Modulator/Potassium Channel Interacting Protein Activity Contribute to Circadian Gene Expression in Pineal Gland J. Neurosci., June 9, 2004; 24(23): 5346 - 5355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Simonneaux and C. Ribelayga Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters Pharmacol. Rev., June 1, 2003; 55(2): 325 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-L. Garidou, B. Vivien-Roels, P. Pevet, J. Miguez, and V. Simonneaux Mechanisms regulating the marked seasonal variation in melatonin synthesis in the European hamster pineal gland Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R1043 - R1052. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Wang and D. R. Storm Calmodulin-Regulated Adenylyl Cyclases: Cross-Talk and Plasticity in the Central Nervous System Mol. Pharmacol., March 1, 2003; 63(3): 463 - 468. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pfeffer, E. Maronde, C. A. Molina, H.-W. Korf, and J. H. Stehle Inducible Cyclic AMP Early Repressor Protein in Rat Pinealocytes: A Highly Sensitive Natural Reporter for Regulated Gene Transcription Mol. Pharmacol., August 1, 1999; 56(2): 279 - 289. [Abstract] [Full Text]
|
|
|
|
|
|
E. Maronde, M. Pfeffer, J. Olcese, C. A. Molina, F. Schlotter, F. Dehghani, H.-W. Korf, and J. H. Stehle Transcription Factors in Neuroendocrine Regulation: Rhythmic Changes in pCREB and ICER Levels Frame Melatonin Synthesis J. Neurosci., May 1, 1999; 19(9): 3326 - 3336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Darvish and J. T. Russell Neurotransmitter-Induced Novel Modulation of a Nonselective Cation Channel by a cAMP-Dependent Mechanism in Rat Pineal Cells J Neurophysiol, May 1, 1998; 79(5): 2546 - 2556. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Brizzolara-Gourdie and J. G. Webb Angiotensin II Potentiates Vasodilation of Rat Aorta by cAMP Elevating Agonists J. Pharmacol. Exp. Ther., April 1, 1997; 281(1): 354 - 359. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Baler, S. Covington, and D. C. Klein The Rat Arylalkylamine N-Acetyltransferase Gene Promoter. cAMP ACTIVATION VIA A cAMP-RESPONSIVE ELEMENT-CCAAT COMPLEX J. Biol. Chem., March 14, 1997; 272(11): 6979 - 6985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Baler and D. C. Klein Circadian Expression of Transcription Factor Fra-2 in the Rat Pineal Gland J. Biol. Chem., November 10, 1995; 270(45): 27319 - 27325. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.A. Checkley and S.B.G. Park The psychopharmacology of the human pineal J Psychopharmacol, January 1, 1987; 1(2): 109 - 125. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Endocrinology | Endocrine Reviews | J. Clin. End. & Metab. |
| Molecular Endocrinology | Recent Prog. Horm. Res. | All Endocrine Journals |
