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Endocrinology, Vol 117, 1602-1607, Copyright © 1985 by Endocrine Society

ARTICLES

Hypercalcemia in rats bearing growth hormone- and prolactin-secreting transplantable pituitary tumors

HE Carlson, SW Lamberts, AS Brickman, LJ Deftos, RL Horst and LR Forte

We evaluated the effects of chronic massive elevations of serum GH and PRL on calcium metabolism in rats bearing the MStT/W15 and 7315a transplantable pituitary tumors. MStT/W15 tumor rats manifest elevated serum GH and PRL levels, hypercalcemia, hypercalciuria, and elevated serum levels of PTH and 1,25-dihydroxyvitamin D. The hypercalcemia was not reversed by dexamethasone or propranolol treatment, but was ameliorated by starvation. Parathyroidectomy produced hypocalcemia in the MStT/W15 tumor rats, confirming the parathyroid dependence of the hypercalcemia. The 7315a tumor produced a milder degree of hypercalcemia, along with elevated serum levels of PRL, ACTH, and corticosterone; serum GH was normal. In high concentrations, PRL and/or GH may stimulate the secretion of PTH as well as enhance dietary calcium absorption, in part through the mediation of 1,25- dihydroxyvitamin D.




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Copyright © 1985 by The Endocrine Society