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Dissociation of Hepatic Messenger Ribonucleic Acid_S14 Levels and Nuclear Transcriptional Rates in Suckling Rats^*

DONALD B. JUMP, T.-Y. TAO, HOWARD C. TOWLE and JACK H. OPPENHEIMER

Division of Endocrinology, Department of Medicine and Department of Biochemistry, University of Minnesota Minneapolis, Minnesota 55455

Address requests for reprints and all correspondence to: Jack H. Oppenheimer, M.D., University of Minnesota Hospitals, Box 91 Mayo Memorial Building, Minneapolis, Minnesota 55455.

Abstract

The messenger RNA (mRNA) coding for the rat hepatic protein spot 14(S14) (mol wt 17,000; pI 4.9) is rapidly responsive to T₃ and carbohydrate administration in the adult animal. In 15-day-old suckling rats, the level of expression is 200-fold less than in 60-day-old chow-fed animals. However, the relative transcriptional activity of the S14 gene is only 30% higher in the 60-day-old rat than in the 15-day-old animal. Although T₃ induces a 100-fold increase in mRNA_S14 in 15-dayold animals, there was only a 17% increase in the S14 gene transcriptional activity. These results indicate that the hormonal and developmental regulation of the S14 gene in liver appears to be predominantly directed at the posttranscriptional level. (Endocrinology 118; 1892–1896, 1986)

Footnotes

^* Supported by NIH Grant AM-19812 (to J.H.O.) and NIH Grant AM-26919 (to H.C.T.).

Present address: Department of Physiology, Michigan State University, East Lansing, Michigan 48824.

Received November 4, 1985.

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