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Endocrinology, Vol 119, 435-437, Copyright © 1986 by Endocrine Society

ARTICLES

Relaxin increases calcium efflux from rat myometrial cells in culture

MR Rao and BM Sanborn

Relaxin and isoproterenol treatment rapidly increased 45Ca2+ efflux from mature rat myometrial cells in culture in a time- and concentration-dependent manner. This effect on Ca2+ efflux was specific for myometrial cells and was not observed in stromal cells isolated from the same uteri. This rapidly exchangeable Ca2+ may be mobilized from a loosely bound peripheral Ca2+ pool in myometrial cells. Relaxin may promote uterine relaxation in part by affecting Ca2+ dynamics in the myometrium.


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Copyright © 1986 by The Endocrine Society