Endocrinology, Vol 119, 1382-1387, Copyright © 1986 by Endocrine Society

ARTICLES

Epidermal growth factor gene expression is regulated differently in mouse kidney and submandibular gland

RM Gubits, PA Shaw, EW Gresik, A Onetti-Muda and T Barka

The concentration of the peptide mitogen epidermal growth factor (EGF) is hormonally and developmentally regulated in the granular convoluted tubule cells of the mouse submandibular gland. Using a labeled EGF nucleic acid probe, we have demonstrated that submandibular gland EGF mRNA concentrations increase during postnatal development of the gland and after the administration of testosterone or thyroid hormone. Recently, it was reported that EGF mRNA is present in kidney as well as a number of other mouse tissues. A comparison of EGF gene regulation in submandibular gland and kidney revealed that kidney EGF mRNA levels also increase during the postnatal period. Opposite sex differences were observed, with submandibular gland levels being about 16-fold higher in the male than in the female and kidney levels being 2- to 4- fold higher in the female than in the male. Renal EGF mRNA concentrations are less responsive to hormones than those in the submandibular gland. Renal EGF was localized immunocytochemically to the cells of distal convoluted tubules.

This article has been cited by other articles:

				N.S. Treister, S.M. Richards, M.J. Lombardi, P. Rowley, R.V. Jensen, and D.A. Sullivan Sex-related Differences in Gene Expression in Salivary Glands of BALB/c Mice J. Dent. Res., February 1, 2005; 84(2): 160 - 165. [Abstract] [Full Text] [PDF]

				A. Nagy, H. Nagashima, S. Cha, G. E. Oxford, T. Zelles, A. B. Peck, and M. G. Humphreys-Beher Reduced Oral Wound Healing in the NOD Mouse Model for Type 1 Autoimmune Diabetes and Its Reversal by Epidermal Growth Factor Supplementation Diabetes, September 1, 2001; 50(9): 2100 - 2104. [Abstract] [Full Text] [PDF]

				L. E. Stern, R. A. Falcone Jr., C. J. Kemp, M. C. Braun, C. R. Erwin, and B. W. Warner Salivary epidermal growth factor and intestinal adaptation in male and female mice Am J Physiol Gastrointest Liver Physiol, June 1, 2000; 278(6): G871 - G877. [Abstract] [Full Text] [PDF]

				S. E. Fenton, N. S. Groce, and D. C. Lee Characterization of the Mouse Epidermal Growth Factor Promoter and 5'-Flanking Region. ROLE FOR AN ATYPICAL TATA SEQUENCE J. Biol. Chem., November 29, 1996; 271(48): 30870 - 30878. [Abstract] [Full Text] [PDF]