help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Khachaturian, H.
Right arrow Articles by Watson, S. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Khachaturian, H.
Right arrow Articles by Watson, S. J.

Endocrinology, Vol 119, 1409-1411, Copyright © 1986 by Endocrine Society

ARTICLES

Pro-dynorphin is endogenous to the anterior pituitary and is co- localized with LH and FSH in the gonadotrophs

H Khachaturian, TG Sherman, RV Lloyd, O Civelli, J Douglass, E Herbert, H Akil and SJ Watson

Pro-dynorphin peptides have been shown to exist in the anterior lobe of the pituitary gland. The dynorphin in the anterior lobe is distinct from that which is co-localized with vasopressin in the magnocellular system in both post-translational processing and regulation of release. Here, we report on the existence of pro-dynorphin mRNA, approximately 2400 nucleotides in length, in the anterior lobe. Furthermore, we present immunocytochemical evidence for the co-existence of dynorphin, LH and FSH in a subset of gonadotrophs. These findings suggest a possible role of pro-dynorphin products in the regulation of the hypothalamic-pituitary-gonadal axis.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
R. Day, C. Lazure, A. Basak, A. Boudreault, P. Limperis, W. Dong, and I. Lindberg
Prodynorphin Processing by Proprotein Convertase 2. CLEAVAGE AT SINGLE BASIC RESIDUES AND ENHANCED PROCESSING IN THE PRESENCE OF CARBOXYPEPTIDASE ACTIVITY
J. Biol. Chem., January 9, 1998; 273(2): 829 - 836.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1986 by The Endocrine Society