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Endocrinology, Vol 119, 1763-1767, Copyright © 1986 by Endocrine Society


ARTICLES

Maternal endocrine extirpations do not abolish maternal coordination of the fetal circadian clock

SM Reppert and WJ Schwartz

The maternal circadian system coordinates the timing of the fetal circadian clock to the prevailing light-dark cycle. The role of various maternal endocrine organs as the source of a coordinating signal was investigated in rats. Either metabolic activity of the fetal suprachiasmatic nuclei or pineal N-acetyltransferase activity in 10-day- old pups was used to monitor the fetal circadian clock. Extirpations of the maternal pituitary, adrenals, thyroid-parathyroids, ovaries, or pineal (each performed in separate experiments) did not abolish maternal coordination.


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