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Endocrinology, Vol 119, 2422-2426, Copyright © 1986 by Endocrine Society

ARTICLES

Prolactin messenger ribonucleic acid levels in the normal and hypogonadal mouse pituitary gland

HF Stanley, A Curtis, WJ Sheward, JL Roberts and G Fink

The effects of estrogen on the synthesis of pituitary PRL mRNA and PRL and the release of PRL into plasma were investigated in male and female normal and hypogonadal (hpg) mice. Because the hpg mouse is totally deficient in hypothalamic GnRH, it provides an excellent model for investigating the effects of estrogen and GnRH on PRL synthesis and release in the presence of a totally inactive gonadotropin-gonadal system. Estrogen stimulated the synthesis and release of pituitary PRL in both sexes of normal and hpg mice, and this marked increase in PRL synthesis correlated with an equally dramatic increase in pituitary PRL mRNA levels. Administration of GnRH alone produced a slight but significant increase in pituitary PRL content, which is consistent with an action of GnRH on prolactotropes, either directly or by way of a paracrine action involving gonadotropes.


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S. Bake, L. Ma, and F. Sohrabji
Estrogen Receptor-{alpha} Overexpression Suppresses 17{beta}-Estradiol-Mediated Vascular Endothelial Growth Factor Expression and Activation of Survival Kinases
Endocrinology, August 1, 2008; 149(8): 3881 - 3889.
[Abstract] [Full Text] [PDF]


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Copyright © 1986 by The Endocrine Society