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Endocrinology, Vol 120, 208-213, Copyright © 1987 by Endocrine Society

ARTICLES

Secretion of proliferin

SJ Lee and D Nathans

Proliferin (PLF) is a member of the PRL-GH family whose mRNA has been detected in proliferating mouse cells in culture and in mouse placenta. Suspensions of murine placental tissue have been shown to produce PLF detectable by immunoprecipitation. Here we report that PLF is secreted as a heterogeneous glycoprotein by growing mouse cell lines and placental tissue and that the first 29 amino acids of the preprotein serve as a signal peptide. Placental PLF is immunologically distinguishable from the 2 previously described mouse placental lactogens.


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 EndocrinologyHome page
D. Jackson and D. I. H. Linzer
Proliferin Transport and Binding in the Mouse Fetus
Endocrinology, January 1, 1997; 138(1): 149 - 155.
[Abstract] [Full Text] [PDF]

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 Genes Dev.Home page
J C Mordacq and D I Linzer
Co-localization of elements required for phorbol ester stimulation and glucocorticoid repression of proliferin gene expression.
Genes & Dev., June 1, 1989; 3(6): 760 - 769.
[Abstract] [PDF]


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