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Endocrinology, Vol 120, 426-428, Copyright © 1987 by Endocrine Society

ARTICLES

Increased atrial natriuretic peptide binding sites in the rat subfornical organ after water deprivation

JM Saavedra, A Israel and M Kurihara

Binding sites for rat atrial natriuretic peptide (99-126) were localized and quantified in the subfornical organ and choroid plexus of control and water-deprived rats. Brain sections were analyzed after incubation with 125I-rat atrial natriuretic peptide (99-126), autoradiography, computerized microdensitometry and comparison to 125I- standards. Higher numbers of atrial natriuretic peptide binding sites were present in both the subfornical organ and the choroid plexus after 4 days of water deprivation. Our results indicate a central role for atrial natriuretic peptide in the regulation of water balance.




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Copyright © 1987 by The Endocrine Society