help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Morales, C.
Right arrow Articles by Griswold, M. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Morales, C.
Right arrow Articles by Griswold, M. D.

Endocrinology, Vol 121, 432-434, Copyright © 1987 by Endocrine Society

ARTICLES

Retinol-induced stage synchronization in seminiferous tubules of the rat

C Morales and MD Griswold

Vitamin A deficiency (VAD) in rats causes a progressive germ cell depletion and cessation of spermatogenesis resulting in seminiferous tubules which contain only Sertoli cells, spermatogonia and a small number of preleptotene spermatocytes. Spermatogenesis can be rapidly restored by the administration of retinol. Our preliminary studies suggested a partial stage synchronization of many seminiferous tubules in VAD male rats subsequently treated with retinol. To confirm this observation and to achieve a better synchronization, VAD rats received 2 SC injections of retinol suspended in sesame oil followed by daily oral administrations of 0.5 mg of retinol. In all rats an almost perfect synchronous stage development of seminiferous tubules evolved in a predictable manner and was maintained through 2 spermiations.


This article has been cited by other articles:


Home page
 DevelopmentHome page
J. Bowles and P. Koopman
Retinoic acid, meiosis and germ cell fate in mammals
Development, October 1, 2007; 134(19): 3401 - 3411.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. Koubova, D. B. Menke, Q. Zhou, B. Capel, M. D. Griswold, and D. C. Page
Inaugural Articles: Retinoic acid regulates sex-specific timing of meiotic initiation in mice
PNAS, February 21, 2006; 103(8): 2474 - 2479.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
H. Khaira, D. McLean, D. A. Ohl, and G. D. Smith
Spermatogonial Stem Cell Isolation, Storage, and Transplantation
J Androl, July 1, 2005; 26(4): 442 - 450.
[Full Text] [PDF]

Home page
 ReproductionHome page
I A Zervos, M P Tsantarliotou, G Vatzias, P Goulas, N A Kokolis, and I A Taitzoglou
Effects of dietary vitamin A intake on acrosin- and plasminogen-activator activity of ram spermatozoa
Reproduction, June 1, 2005; 129(6): 707 - 715.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
K.-F. Lee, W. S.B. Yeung, J. F.C. Chow, C. K. Shum, and J. M. Luk
Different Testicular Gene Expression Patterns in the First Spermatogenic Cycle of Postnatal and Vitamin A-Deficient Rat Testis
Biol Reprod, April 1, 2004; 70(4): 1010 - 1017.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Kanatsu-Shinohara, S. Toyokuni, and T. Shinohara
CD9 Is a Surface Marker on Mouse and Rat Male Germline Stem Cells
Biol Reprod, January 1, 2004; 70(1): 70 - 75.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. M. Dufour, M.-N. Vo, N. Bhattacharya, J. Okita, R. Okita, and K. H. Kim
Peroxisome Proliferators Disrupt Retinoic Acid Receptor Alpha Signaling in the Testis
Biol Reprod, April 1, 2003; 68(4): 1215 - 1224.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. H. G. J. Schrans-Stassen, H. J. G. van de Kant, D. G. de Rooij, and A. M. M. van Pelt
Differential Expression of c-kit in Mouse Undifferentiated and Differentiating Type A Spermatogonia
Endocrinology, December 1, 1999; 140(12): 5894 - 5900.
[Abstract] [Full Text]

Home page
 Biol. Reprod.Home page
J. M. Dufour and K. H. Kim
Cellular and Subcellular Localization of Six Retinoid Receptors in Rat Testis During Postnatal Development: Identification of Potential Heterodimeric Receptors
Biol Reprod, November 1, 1999; 61(5): 1300 - 1308.
[Abstract] [Full Text]

Home page
 EndocrinologyHome page
I. C. Gaemers, E. Sonneveld, A. M. M. van Pelt, B. H. G. J. Schrans, A. P. N. Themmen, P. T. van der Saag, and D. G. de Rooij
The Effect of 9-cis-Retinoic Acid on Proliferation and Differentiation of A Spermatogonia and Retinoid Receptor Gene Expression in the Vitamin A-Deficient Mouse Testis
Endocrinology, October 1, 1998; 139(10): 4269 - 4276.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
K. M. Akmal, J. M. Dufour, M. Vo, S. Higginson, and K. H. Kim
Ligand-Dependent Regulation of Retinoic Acid Receptor {alpha} in Rat Testis: In Vivo Response to Depletion and Repletion of Vitamin A
Endocrinology, March 1, 1998; 139(3): 1239 - 1248.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
I. C. Gaemers, A. M. M. van Pelt, P. T. van der Saag, J. W. Hoogerbrugge, A. P. N. Themmen, and D. G. de Rooij
Effect of Retinoid Status on the Messenger Ribonucleic Acid Expression of Nuclear Retinoid Receptors {alpha}, {beta}, and {gamma}, and Retinoid X Receptors {alpha}, {beta}, and {gamma} in the Mouse Testis
Endocrinology, April 1, 1997; 138(4): 1544 - 1551.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Wei, V. Episkopou, R. Piantedosi, S. Maeda, K. Shimada, M. E. Gottesman, and W. S. Blaner
Studies on the Metabolism of Retinol and Retinol-binding Protein in Transthyretin-deficient Mice Produced by Homologous Recombination
J. Biol. Chem., January 13, 1995; 270(2): 866 - 870.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1987 by The Endocrine Society