help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology, doi:10.1210/endo-121-6-2141
Endocrinology Vol. 121, No. 6 2141-2144
Copyright © 1987 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Submit a related Letter to the Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Reprints, Permissions and Rights
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by ROTWEIN, P.
Right arrow Articles by MILBRANDT, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by ROTWEIN, P.
Right arrow Articles by MILBRANDT, J. D.

Insulin-Like Growth Factor Gene Expression during Rat Embryonic Development*

PETER ROTWEIN, KAREN M. POLLOCK, MARK WATSON{dagger} and JEFFREY D. MILBRANDT{ddagger}

Departments of Medicine, Genetics, and Pathology, Washington University School of Medicine St. Louis, Missouri 63110

Address requests for reprints to: Dr. Peter Rotwein, Departments of Internal Medicine and Genetics, Washington University, 660 South Euclid Avenue, Box 8127, St. Louis, Missouri 63110.

Abstract

The function of insulin-like growth factors I and II (IGF-I and IGF-II) in embryogenesis is unknown. To investigate the ontogeny of IGF gene expression during mammalian development we used a highly sensitive and specific solutionhybridization assay to determine the steady state levels of IGF mRNAs during midgestation in the rat. IGF-I mRNA can be detected as early as day 11 of embryonic development and rises 8.6-fold over the ensuing 48 h. By contrast IGF-II mRNA is relatively constant over days 11-14 of gestation. These observations suggest that both IGFs may play important roles in early fetal development. (Endocrinology 121: 2141–2144, 1987)

Footnotes

* This work was supported in part by NIH Grants DK-37449 and HD-20805 (to P.R.).

{dagger} Supported by Medical Scientist Training Program Grant GM-07200.

{ddagger} Recipient of NIH Clinical Investigator Development Award (NS-01018).

Received August 5, 1987.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. Shen, D. Mallon, D. W. Boyle, and E. A. Liechty
IGF-I and insulin regulate eIF4F formation by different mechanisms in muscle and liver in the ovine fetus
Am J Physiol Endocrinol Metab, September 1, 2002; 283(3): E593 - E603.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
S. J. Servoss, S. J. Lee, G. Gibney, I. Gozes, D. E. Brenneman, and J. M. Hill
IGF-I as a Mediator of VIP/Activity-Dependent Neurotrophic Factor-Stimulated Embryonic Growth
Endocrinology, August 1, 2001; 142(8): 3348 - 3353.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
L Powell-Braxton, P Hollingshead, C Warburton, M Dowd, S Pitts-Meek, D Dalton, N Gillett, and T A Stewart
IGF-I is required for normal embryonic growth in mice.
Genes & Dev., December 1, 1993; 7(12b): 2609 - 2617.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
D A Rappolee, K S Sturm, O Behrendtsen, G A Schultz, R A Pedersen, and Z Werb
Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos.
Genes & Dev., June 1, 1992; 6(6): 939 - 952.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1987 by The Endocrine Society