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REPEATED STRESS INCREASES THE DENSITY OF ANGIOTENSIN I I BINDING SITES IN RAT PARAVENTRICULAR NUCLEUS AND SUBFORNICAL ORGAN

Unit on Preclinical Neuropharmacology, Section on Clinical Pharmacology, Laboratory of Clinical Science, National Institute of Mental Health Bethesda, MD 20892

Address for correspondence: NIH, 9000 Rockville Pike, Building 10, Room 2046, Bethesda, MD 20892

Abstract

We have studied the properties of angiotensin II binding sites in the paraventricular nucleus, subfornical organ and anterior pituitary lobe of rats subjected to repeated immobilization stress. This treatment produced significant increase in the density of angiotensin I I binding sites in these two nuclei without any significant alteration in binding affinity. Repeated stress did not alter angiotensin II binding properties in the anterior pituitary lobe. Our results suggest that brain angiotensin binding sites may have a role in regulation of the stress response.

Received July 24, 1987.

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