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Endocrinology, Vol 122, 500-503, Copyright © 1988 by Endocrine Society

ARTICLES

Estradiol stimulates a uterine plasma membrane protease activator

EE Jazin, HW Dickerman and KP Henrikson
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201.

An estrogen-regulated arginine esteropeptidase is present in the immature rat uterus. The enzymatic complex consists of a membrane-bound activator and a soluble proenzyme. The activator is under strong estrogen control; its activity increases 10-fold 3 h after a single dose of 17 beta-estradiol. The subcellular localization of the activator is determined by a radioactive assay of fractions prepared by sucrose density centrifugation. The distribution of activity parallels the distribution of two plasma membrane markers, Mg2+-ATPase and 5'- nucleotidase. Electron micrographic visualization of the gradient fractions containing the activator reveals a population of vesicles 0.2- 0.5 micron in diameter.




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Endocrinology Endocrine Reviews J. Clin. End. & Metab.
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Copyright © 1988 by The Endocrine Society