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Endocrinology, Vol 122, 563-566, Copyright © 1988 by Endocrine Society

ARTICLES

Virus-induced thyroiditis

J Srinivasappa, C Garzelli, T Onodera, U Ray and AL Notkins
Laboratory of Oral Medicine, National Institute of Dental Research, Bethesda, Maryland 20892.

Mice infected with reovirus type 1 developed a mild thyroiditis characterized by focal destruction of acinar tissue, infiltration of inflammatory cells, and autoantibodies to thyroglobulin and microsomal antigens. Thyroid involvement appears to be part of a more generalized virus-induced polyendocrine disease.


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