Endocrinology, Vol 122, 1185-1187, Copyright © 1988 by Endocrine Society

ARTICLES

Tumor necrosis factor-a (TNF-a) production and localization of macrophages and T lymphocytes in the rabbit corpus luteum

P Bagavandoss, SL Kunkel, RC Wiggins and PL Keyes
Department of Physiology, University of Michigan, Ann Arbor 48109.

Utilizing immunocytochemistry numerous macrophages were localized in regressing corpora lutea. In contrast, few macrophages were observed in young corpora lutea. Regressing corpora lutea readily produced TNF-a in vitro in response to lipopolysaccharide, whereas young corpora lutea produced significantly less TNF-a. T lymphocytes were identified in young corpora lutea preceding the appearance of macrophages. These observations suggest that cells of the immune system and cytokines could be important participants in physiological regression of the corpus luteum.

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