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Endocrinology, Vol 123, 227-229, Copyright © 1988 by Endocrine Society

ARTICLES

Localization of pancreastatin immunoreactivity in porcine endocrine cells

M Ravazzola, S Efendic, CG Ostenson, K Tatemoto, JC Hutton and L Orci
Institute of Histology and Embryology, University of Geneva Medical School, Switzerland.

Pancreastatin is a peptide isolated from the porcine pancreas and shown to inhibit insulin release. We have studied the immunocytochemical distribution of pancreastatin in three porcine endocrine tissues: pancreas, gut, and adenohypophysis. Pancreastatin-specific immunoreactivity was found in all three locations and distributed to numerous cells. In the pancreas, we performed the alternate labeling of consecutive thick (immunofluorescence) or thin (protein A-gold) sections and we observed that pancreastatin colocalizes to secretory granules of insulin and somatostatin-containing cells. The relationship of pancreastatin to chromogranin A is discussed.


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V. Sanchez-Margalet and J. Santos-Alvarez
Solubilization and Molecular Characterization of Active Pancreastatin Receptors from Rat Liver Membranes
Endocrinology, April 1, 1997; 138(4): 1712 - 1718.
[Abstract] [Full Text] [PDF]


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