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Endocrinology, Vol 124, 558-560, Copyright © 1989 by Endocrine Society

ARTICLES

Identification of immunoreactive gastrin-releasing peptide related substances in adult rat Leydig cells

L Gnessi, A Isidori, M Bolotti, S Altamura, S Ulisse, EA Jannini, A Fabbri and G Spera
Department of Andrology, Policlinico Umberto I, University of Rome La Sapienza, Italy.

Purified adult rat Leydig cells were found to produce gastrin-releasing peptide (GRP) by radioimmunoassay (RIA). Gel chromatography of the extracted material showed a single peak of GRP immunoreactivity. Further high pressure liquid chromatography (HPLC) analysis resolved the extract into two peaks that closely resembled the C-terminal fragment of GRP, GRP18-27 and GRP14-27. Immunohistochemical studies revealed specific staining for GRP in the Leydig cells of adult rat testis. These results demonstrate, by a number of independent criteria, that rat Leydig cells contain substances which behave like authentic GRP-like peptides. Since the peptides appear to be of local origin, a paracrine function within the rat testis is suggested.


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