help button home button Endocrine Society Endocrinology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS

Endocrinology, doi:10.1210/endo-124-1-60
Endocrinology Vol. 124, No. 1 60-68
Copyright © 1989 by the Endocrine Society.
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Copyright Permission
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by GRINO, M.
Right arrow Articles by BURGUNDER, J.-M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by GRINO, M.
Right arrow Articles by BURGUNDER, J.-M.

Ontogeny of Expression of the Corticotropin-Releasing Factor Gene in the Hypothalamic Paraventricular Nucleus and of the Proopiomelanocortin Gene in Rat Pituitary

MICHEL GRINO, W. SCOTT YOUNG, III and JEAN-MARC BURGUNDER

Unit on Molecular and Cellular Neurobiology (M.G.), Laboratory of Cell Biology, National Institute of Mental Health, National Institutes of Health Bethesda, Maryland 20892

Address all correspondence and requests for reprints to: M. Grino, Laboratory of Cell Biology, National Institute of Mental Health, Building 36, Room 3A17, Bethesda, Maryland 20892.

Abstract

The ontogeny of expression of the CRF gene in the paraventricular hypothalamic nucleus and POMC gene in the pituitary was studied in rats using in situ hybridization histochemistry and Northern blotting techniques, respectively. CRF mRNA was first detected on day 17 of gestation (E17) in the paraventricular nucleus of the hypothalamus. The levels of hypothalamic CRF mRNA increased progressively from E17 to E19-E20, decreased during the perinatal period, and increased thereafter.

The levels of POMC mRNA in the pituitary paralleled the variations in hypothalamic CRF mRNA, showing a peak on E20-E21. POMC mRNA levels in the anterior pituitary were decreased on days 4–7 after birth (P4–P7) and increased steadily thereafter. In contrast to levels in the anterior pituitary, POMC mRNA levels increased steadily from PI to P21 in the neurointermediate lobe of the pituitary.

These data indicate that the expression of both the CRF and POMC genes in the paraventricular nucleus and anterior pituitary, respectively, are reduced during the first week of life, i.e. within the so-called stress nonresponsive period. Our observations suggest that an impaired regulation of ACTH and CRF synthesis due to an immature neuronal pathway within the brain or increased glucocorticoid feedback may account for the stress nonresponsive period. (Endocrinology 124: 60–68,1989)

Received June 9, 1988.




This article has been cited by other articles:


Home page
Poult. Sci.Home page
F. Z. Lu, X. X. Wang, Q. X. Pan, R. H. Huang, and H. L. Liu
Expression of Genes Involved in the Somatotropic, Thyrotropic, and Corticotropic Axes During Development of Langshan and Arbor Acres Chickens
Poult. Sci., October 1, 2008; 87(10): 2087 - 2097.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
F. Remmers, L. A. W. Verhagen, R. A. H. Adan, and H. A. Delemarre-van de Waal
Hypothalamic Neuropeptide Expression of Juvenile and Middle-Aged Rats after Early Postnatal Food Restriction
Endocrinology, July 1, 2008; 149(7): 3617 - 3625.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
M. Schmidt, S. Levine, M. S. Oitzl, M. van der Mark, M. B. Muller, F. Holsboer, and E. R. de Kloet
Glucocorticoid Receptor Blockade Disinhibits Pituitary-Adrenal Activity during the Stress Hyporesponsive Period of the Mouse
Endocrinology, March 1, 2005; 146(3): 1458 - 1464.
[Abstract] [Full Text] [PDF]


Home page
J EndocrinolHome page
R. Guillemin
Hypothalamic hormones a.k.a. hypothalamic releasing factors
J. Endocrinol., January 1, 2005; 184(1): 11 - 28.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
K. Vandenborne, B. De Groef, S. M. E. Geelissen, G. C. Boorse, R. J. Denver, E. R. Kuhn, V. M. Darras, and S. Van der Geyten
Molecular Cloning and Developmental Expression of Corticotropin-Releasing Factor in the Chicken
Endocrinology, January 1, 2005; 146(1): 301 - 308.
[Abstract] [Full Text] [PDF]


Home page
EndocrinologyHome page
M. F. Dallman
Editorial: Moments in Time--The Neonatal Rat Hypothalamo-Pituitary-Adrenal Axis
Endocrinology, May 1, 2000; 141(5): 1590 - 1592.
[Full Text] [PDF]


Home page
EndocrinologyHome page
M. A. Smith, S.-Y. Kim, H. J. J. van Oers, and S. Levine
Maternal Deprivation and Stress Induce Immediate Early Genes in the Infant Rat Brain
Endocrinology, November 1, 1997; 138(11): 4622 - 4628.
[Abstract] [Full Text] [PDF]


Home page
Genes Dev.Home page
M D Schonemann, A K Ryan, R J McEvilly, S M O'Connell, C A Arias, K A Kalla, P Li, P E Sawchenko, and M G Rosenfeld
Development and survival of the endocrine hypothalamus and posterior pituitary gland requires the neuronal POU domain factor Brn-2.
Genes & Dev., December 15, 1995; 9(24): 3122 - 3135.
[Abstract] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Endocrinology Endocrine Reviews J. Clin. End. & Metab.
Molecular Endocrinology Recent Prog. Horm. Res. All Endocrine Journals
Copyright © 1989 by The Endocrine Society